Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib.

Jung Woo Eun,Jung Hwan Yoon,Hye Ri Ahn,Seokhwi Kim,Young Bae Kim,Su Bin Lim, Won Park, Tae Wook Kang,Geum Ok Baek,Moon Gyeong Yoon,Ju A Son, Ji Hyang Weon,Soon Sun Kim,Hyo Jung Cho,Jae Youn Cheong

Cancer communications (London, England)（2023）

引用 13|浏览16

暂无评分

摘要

CAF-derived SPP1 enhances TKI resistance in HCC via bypass activation of oncogenic signals and EMT promotion. Its inhibition represents a promising therapeutic strategy against TKI resistance in HCC. Moreover, plasma SPP1 level before TKI treatment represents a potential biomarker for treatment response prediction.

查看译文

关键词

drug resistance,epithelial-to-mesenchymal transition,hepatocellular carcinoma,secreted phosphoprotein 1

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要