STING is ESCRTed to degradation by microautophagy

Activation of a crucial immune adaptor protein, STING, is tightly regulated by subcellular trafficking, but how it is deactivated remains less well defined. A study now shows that ESCRT-dependent encapsulation of STING-carrying vesicles by lysosomal compartments - through the process of microautophagy - mediates the termination of STING signalling.