KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer.

Hong Qiu,Vladimir Makarov,Jennifer K Bolzenius,Angela Halstead,Yvonne Parker,Allen Wang,Gopakumar V Iyer,Hannah Wise,Daniel Kim,Varna Thayaparan,Daniel J Lindner,Georges-Pascal Haber,Angela H Ting,Bing Ren,Timothy A Chan,Vivek Arora,David B Solit,Byron H Lee

Cancer research（2023）

引用 5|浏览37

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摘要

A gain-of-function epigenetic switch that disrupts differentiation is triggered by inactivating KDM6A mutations in bladder cancer and can serve as a potential target for novel therapies.

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关键词

bladder cancer,disrupts urothelial differentiation,epigenetic switch,drives cell proliferation

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