Bioinformatics Insights on the Physicochemical Properties of SCN5A Mutant Proteins Associated with the Brugada Syndrome.

Carlos Polanco,Manlio F Márquez,Vladimir N Uversky,Enrique H Lemus,Alberto Huberman,Thomas Buhse, Martha R Castro

Current medicinal chemistry（2023）

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摘要

Bioinformatics programs could reproduce characteristic PIM and PIDP profiles of the BrS-related SCN5A mutant proteins. This information can contribute to a better understanding of these altered proteins.

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关键词

SCN5A,SCN5A gene,SNC5A mutant proteins,bioinformatics,intrinsic disorder predisposition profile,polarity index method profile,structural proteomics

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