Genetic and immune microenvironment characterization of HER2-positive gastric cancer: Their association with response to trastuzumab-based treatment.

Hyun Jung Kwon,Yujun Park,Soo Kyung Nam,Enoch Kang,Ka-Kyung Kim, Inhae Jeong,Yoonjin Kwak,Jeesun Yoon,Tae-Yong Kim,Keun-Wook Lee,Do-Youn Oh,Seock-Ah Im,Seong-Ho Kong,Do Joong Park,Hyuk-Joon Lee,Hyung-Ho Kim,Han-Kwang Yang,Hye Seung Lee

Cancer medicine（2023）

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摘要

HER2-positive GC with favorable response to trastuzumab were characterized by cell cycle-related gene alterations and increased CD3 CD57 NK cell infiltration. These findings would be helpful to the fine modulation of therapeutic strategies for patients with HER2-positive GC.

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关键词

HER2-positive gastric cancer,NK cell,PD-L1,cell cycle,trastuzumab

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