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Long noncoding RNA SPRY4-IT1 acts as a miR-101-5p sponge to promote gastrointestinal stromal tumor progression by inhibiting ZEB1.

Chen Huang,Ming Wang,Wen-Yi Zhao,Yan-Ying Shen,Chun Zhuang,Bo Ni,Lin-Xi Yang,Lu Lu,Xiao-Qi Li,Lin Tu,Hui Cao

American journal of translational research（2023）

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Abstract
In GIST, we revealed a ceRNA mechanism by which SPRY4-IT1 modulates ZEB1 by sponging miR-101-5p, eventually driving tumor cell proliferation, migration, and epithelial-mesenchymal transition (EMT).
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ERK,GIST,SPRY4,SPRY4-IT1,ZEB1,miR-101-5p
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