CDKN2A/B co-deletion is associated with increased risk of local and distant intracranial recurrence after surgical resection of brain metastases.

Ramin A Morshed,Minh P Nguyen,Daniel D Cummins,Satvir Saggi,Jacob S Young,Alexander F Haddad,Ezequiel Goldschmidt,Edward F Chang,Michael W McDermott,Mitchel S Berger,Philip V Theodosopoulos,Shawn L Hervey-Jumper,Mariza Daras,Manish K Aghi

Neuro-oncology advances（2023）

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摘要

co-deletion detected in BMs is associated with increased CNS recurrence after surgical resection. Additional work is needed to determine whether more aggressive treatment in patients with this mutation may improve outcomes.

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关键词

CDKN2A,CDKN2B,brain metastasis,distant recurrence,local recurrence,surgery

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