Up-regulation of PUM1 by miR-218-5p promotes colorectal tumor-initiating cell properties and tumorigenesis by regulating the PI3K/AKT axis.

Qi-Zhi Liu, Hai-Rong Yu,Li-Ping Wang,Min-Jun Zhou,Zhuo Chen,De-Hua Zhou,Jun-Yi Chen,Nan Zhang,Zhen-Xing Huang, Yu-Xiang Xie, Fang-Fang Gu,Kun Li,Xiao-Huang Tu

Journal of gastrointestinal oncology（2023）

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摘要

Taken together, the result of this work points to the critical function of the miR-218-5p/PUM1/PI3K/AKT regulatory circuit in regulating T-ICs characteristics and thus suggests possible therapeutic targets for CRC.

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关键词

Pumilio homologous protein 1 (PUM1),biomarker,cetuximab,colorectal cancer (CRC),tumor-initiating cells (T-ICs)

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