Eukaryotic Initiation Factor 5A2 localizes to actively translating ribosomes to promote cancer cell protrusions and invasive capacity.

Arantxa Martínez-Férriz,Carolina Gandía,José Miguel Pardo-Sánchez,Alihamze Fathinajafabadi,Alejandro Ferrando,Rosa Farràs

Cell communication and signaling : CCS（2023）

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摘要

We propose the existence of a coordinated temporal and positional interaction between TFGB and eIF-5A2 pathways to promote cell migration in NSCLC. We suggest that the co-localization of actively translating ribosomes with hypusinated eIF-5A2 facilitates the translation of key proteins not only in the cytosol but also in areas of cellular protrusion. Video Abstract.

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关键词

Cell migration,Cytoskeleton organization,Eukaryotic translation initiation factor 5A2,Lung adenocarcinoma,TGFB1 signaling,Translating ribosomes

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