A FluoroSpot B assay for the detection of IgA and IgG SARS-CoV-2 spike-specific memory B cells: Optimization and qualification for use in COVID-19 vaccine trials.

Hélène Bisceglia, Julie Barrier,Joseline Ruiz,Anke Pagnon

Journal of immunological methods（2023）

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摘要

These results show that the dual-color IgA-IgG FluoroSpot provides a sensitive, specific, linear, and precise tool to detect spike-specific MBC responses. This MBC FluoroSpot assay is a method of choice for monitoring spike-specific IgA and IgG MBC responses induced by COVID-19 candidate vaccines in clinical trials.

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关键词

Assay optimization,COVID-19,FluoroSpot,Memory B cells,Qualification,SARS-CoV-2 spike

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