Moshen granule ameliorates membranous nephropathy by blocking intrarenal renin-angiotensin system signalling via the Wnt1/β-catenin pathway.
Phytomedicine（2023）
Abstract
This study first demonstrates that AGS mitigates podocyte injury by inhibiting the activation of RAS signalling via the Wnt1/β-catenin pathway by both pharmacological and genetic methods. Therefore, AGS might be considered a new β-catenin inhibitor that inhibits the Wnt1/β-catenin pathway to retard MN in patients.
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Key words
Astragaloside IV,Cationic bovine serum albumin,Membranous nephropathy,Moshen granule,Renin-angiotensin system,Wnt1/β-catenin pathway
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