Histone deacetylase 8 inhibition prevents the progression of peritoneal fibrosis by counteracting the epithelial-mesenchymal transition and blockade of M2 macrophage polarization.
Frontiers in immunology（2023）
Abstract
We demonstrated that HDAC8 promoted the EMT of HPMCs via EGFR/ERK1/2/STAT3/HIF-1α, induced M2 macrophage polarization via STAT6 and PI3K/Akt signaling pathways, and ultimately accelerated the process of peritoneal fibrosis.
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Key words
epidermal growth factor receptor,epithelial-mesenchymal transition,histone deacetylase 8,macrophage polarization,peritoneal fibrosis
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