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Adherent-invasive E. coli - induced specific IgA limits pathobiont localization to the epithelial niche in the gut.

Rika Tanaka,Jin Imai,Hitoshi Tsugawa, Karl Bil Eap,Masaki Yazawa,Motoki Kaneko,Masashi Ohno,Kohei Sugihara,Sho Kitamoto,Hiroko Nagao-Kitamoto,Nicolas Barnich,Masashi Matsushima,Takayoshi Suzuki,Tatehiro Kagawa,Yasuhiro Nishizaki,Hidekazu Suzuki,Nobuhiko Kamada,Katsuto Hozumi

Frontiers in microbiology（2023）

Cited 2|Views32
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Abstract
These results demonstrate that host immunity selectively recognizes pathobiont , such as AIEC, and develop specific IgA. The induced IgA specific to pathobiont , in turn, contributes to preventing the pathobionts from accessing the epithelium.
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Key words
Crohn’s disease,IgA,adherent invasive E coli,host-pathogen interaction,inflammatory bowel disease,pathobiont
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