ITPA Polymorphisms and the Incidence of Toxicities in Children with Acute Lymphoblastic Leukemia.

Patpetra Svasdisant,Waraporn Glomglao,Preeyanun Siraprapapat,Wiyakan Inthararujikul,Kalaya Tachavanich,Chetsada Boonthimat,Sakkarin Ardsiri, Kochpinchon Chansing, Suwimon Sriprach,Sasima Tongsai,Phakatip Sinlapamongkolkul,Kleebsabai Sanpakit,Jassada Buaboonnam

Mediterranean journal of hematology and infectious diseases（2023）

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摘要

Hom had a higher incidence of transaminitis and required a significantly larger dose reduction of 6-MP than wild-type . Further study is warranted to elucidate the effects of polymorphisms on toxicity in patients with ALL treated with 6-MP.

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关键词

Inosine triphosphate pyrophosphatase,Leukemia,Mercaptopurine,Neutropenia,Transaminitis

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