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Potent bromodomain and extraterminal domain inhibitor JAB-8263 suppresses MYC expression and exerts anti-tumor activity in colorectal cancer models.

Xin-Mo Liu,Shao-You Xia, Wei Long,Hai-Jun Li, Gui-Qun Yang,Wen Sun,Song-Yan Li,Xiao-Hui Du

World journal of gastrointestinal oncology（2023）

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Abstract
BET could be a potential effective drug target for suppressing CRC growth, and the BET inhibitor JAB-8263 can effectively suppress c-MYC expression and exert anti-tumor activity in CRC models.
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Bromodomain,Bromodomain and extraterminal domain inhibitor,Colorectal cancer,JAB-8263,MYC,p21
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