METTL5 stabilizes c-Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression.

Peng Xia,Hao Zhang,Haofeng Lu,Kequan Xu,Xiang Jiang, Yuke Jiang,Xiangdong Gongye,Zhang Chen,Jie Liu,Xi Chen,Weijie Ma,Zhonglin Zhang,Yufeng Yuan

Cancer communications (London, England)（2023）

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摘要

These findings point to a novel mechanism by which CREB1/P300-METTL5-USP5-c-Myc controls abnormal glucose metabolism and promotes tumor growth, suggesting that METTL5 is a potential therapeutic target and prognostic biomarker for HCC.

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关键词

CREB1,METTL5,P300,USP5,c-Myc,deubiquitination,glucose metabolism,hepatocellular carcinoma

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