Incidence of cardiovascular events in men with BCR following a radical prostatectomy: ADT versus no ADT

You have accessJournal of UrologyCME1 Apr 2023MP29-11 INCIDENCE OF CARDIOVASCULAR EVENTS IN MEN WITH BCR FOLLOWING A RADICAL PROSTATECTOMY: ADT VERSUS NO ADT Joshua Tran, Rafael Gevorkyan, Erica Huang, Robert Wilson, Sheldon Greenfield, Linda Huynh, and Thomas Ahlering Joshua TranJoshua Tran More articles by this author , Rafael GevorkyanRafael Gevorkyan More articles by this author , Erica HuangErica Huang More articles by this author , Robert WilsonRobert Wilson More articles by this author , Sheldon GreenfieldSheldon Greenfield More articles by this author , Linda HuynhLinda Huynh More articles by this author , and Thomas AhleringThomas Ahlering More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003257.11AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Androgen deprivation therapy (ADT) is frequently recommended for biochemical recurrence (BCR) following a radical prostatectomy (RP). The most severe life-threatening complication of ADT is an adverse cardiovascular event (ACE) such as acute myocardial infarction, stroke, etc. There exists a conflict between the relationship of PC, ADT and ACEs in the literature. This study seeks to assess the relationship of ACE and cardiovascular mortality (CM) in men undergoing ADT post-RP. METHODS: Retrospective review of prospectively collected data (n = 1895) from patients who underwent robot-assisted radical prostatectomy (RARP) performed by a single surgeon. 308/407 with BCR and adequate follow-up data were analyzed. 189/271 men in the “treatment group” (TG) were managed with ADT. The comparator group was 119/136 with no treatment (AO). Regression and Kaplan Meier (KM) analyses were performed. RESULTS: At time of surgery, there were no significant differences in Charlson comorbidity index (CCI) but a trend in favor of AO (4.14 versus 4.38; /Table 1/). Significant predictors of ACEs in univariate analysis were age, CCI, body mass index (BMI), treatment status (AO vs TG), and smoking status (non-smoker vs previous smoker; Table 2). 15-year KM analysis showed a statistically significant increase in ACEs (TG 54.4% and AO 41.8%, p = 0.02; Figure 1). In adjusted analysis, CCI and BMI were significant predictors for ACE with treatment trending toward significance. No differences in CM were observed. CONCLUSIONS: Although BCR was associated with increased acute cardiovascular events, remarkably this was not observed in CM. We also noted the importance of BMI and CCI as a prognosticating tool for predicting acute cardiovascular events. Source of Funding: N/A © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e385 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Joshua Tran More articles by this author Rafael Gevorkyan More articles by this author Erica Huang More articles by this author Robert Wilson More articles by this author Sheldon Greenfield More articles by this author Linda Huynh More articles by this author Thomas Ahlering More articles by this author Expand All Advertisement PDF downloadLoading ...