GSH-responsive and O2-economizing virus-like nanocapsule for photothermal-augmented sonodynamic therapy

Jiajing Liu,Mengqi Li,Zhiyu Zhao,Xian Luo,Li Wang,Tingting Li, Cong Liu,Shengyu Wang,Ting Wu, Dong Yang,Yang Li,Peiyuan Wang,Jianghua Yan,Fanghong Luo

Chemical Engineering Journal（2023）

Cited 6|Views19

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Abstract

•The virus-like surface-assisted active targeting enhanced cellular internalization.•Tetra-sulfide-bridged nanocaspule with effective GSH-depletion to adjust the ROS.•ATO can significantly reduce the O2 consumption to improve the efficiency of SDT.•The nanocaspule presented multi-mode imaging and PTT-augmented SDT on tumor.

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Key words

O2-economizer,GSH responsiveness,Virus-inspired nanocapsule,Oxidative stress amplification,Photothermal-augmented sonodynamic therapy

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