Prognostic value of circulating T-lymphocyte subsets in advanced pancreatic cancer patients treated with mFOLFIRINOX or gemcitabine

Skaiste Tulyte,Dainius Characiejus,Reda Matuzeviciene,Ausra Janiulioniene,Mantas Radzevicius, Elena Jasiunaite,Tadas Zvirblis,Audrius Sileikis

International Immunopharmacology（2023）

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摘要

•Circulating CD8 + CD57- cells in PDAC may be considered a prognostic and predictive biomarker.•In survival analysis for OS, significant factors included absolute blood WBC, CD3 + CD8 + and CD8 + CD57- T lymphocytes.•Number of NK CD3-CD56 + CD16 + and CD3-CD56 + CD16- and T regulatory CD4 + FOXP3 + cells and CD3 + CD56 + differed during treatment.•Gemcitabine led to better survival in patients with extremely low baseline CD8 + CD57- values.

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关键词

Pancreatic adenocarcinoma,Lymphocytes,T cells,Gemcitabine,FOLFIRINOX

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