TP53 Mutations Are Associated with Increased Infections and Reduced Hematopoietic Cell Transplantation Rates in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Jennifer Marvin-Peek,Emily F. Mason,Ashwin Kishtagari,Reena V. Jayani,Bhagirathbhai Dholaria,Tae Kon Kim,Brian G. Engelhardt,Heidi Chen,Stephen Strickland,Bipin Savani,Brent Ferrell,Adetola Kassim,Michael Savona,Sanjay Mohan, Michael Byrne

Transplantation and Cellular Therapy（2023）

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摘要

•Infections are more common in patients with TP53 mutations in myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML).•Infection is an independent risk factor for reduced transplantation rate.•Infections are associated worse overall survival in patients with TP53MUT MDS/AML.

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TP53 mutation,Myelodysplastic syndrome,Acute myeloid leukemia

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