Risk stratification and molecular heterogeneity of endometrial cancer and expression profile of TIM-3: A retrospective cohort study.

Yubo Zhang,Ruiye Yang,Chunyu Xu,Yanqin Zhang,Mengqi Deng,Di Wu,Fan Tang, Xinyu Liu,Yiding Han,Yang Zhan,Jinwei Miao

Gynecologic oncology（2023）

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摘要

Our study revealed the molecular heterogeneity across subtypes and subgroups. The new risk stratification system changed the risk grouping of some patients due to the integration of molecular features. RAD51B mutation can further stratify the recurrence risk in the p53wt subtype. Patients with MMRd or POLEmut may benefit most from immunotherapy against TIM-3.

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关键词

Endometrial cancer,Gene mutations,Molecular subtypes,Risk groups,TIM-3

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