An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones

Dmitrii A. Aksenov,Alesia S. Akulova,Elena A. Aleksandrova,Nicolai A. Aksenov,Alexander V. Leontiev,Alexander V. Aksenov

Molecules (Basel, Switzerland)（2023）

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Abstract

A straightforward three-step procedure affording a wide range of novel 7-aryl substituted paullone derivatives was developed. This scaffold is structurally similar to 2-(1H-indol-3-yl)acetamides-promising antitumor agents-hence, could be useful for the development of a new class of anticancer drugs.

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Key words

Fisher indolization,paullones synthesis,anticancer drug discovery

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