Microbiota of Urine, Glans and Prostate Biopsies in Patients with Prostate Cancer Reveals a Dysbiosis in the Genitourinary System.

Cancers(2023)

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摘要
Prostate cancer (PCa) is the most common malignant neoplasm with the highest worldwide incidence in men aged 50 years and older. Emerging evidence suggests that the microbial dysbiosis may promote chronic inflammation linked to the development of PCa. Therefore, this study aims to compare the microbiota composition and diversity in urine, glans swabs, and prostate biopsies between men with PCa and non-PCa men. Microbial communities profiling was assessed through 16S rRNA sequencing. The results indicated that α-diversity (number and abundance of genera) was lower in prostate and glans, and higher in urine from patients with PCa, compared to non-PCa patients. The different genera of the bacterial community found in urine was significantly different in PCa patients compared to non-PCa patients, but they did not differ in glans and prostate. Moreover, comparing the bacterial communities present in the three different samples, urine and glans show a similar genus composition. Linear discriminant analysis (LDA) effect size (LEfSe) analysis revealed significantly higher levels of the genera , , , , , , and in urine of PCa patients, whereas /, , and were more abundant in the non-PCa patients. In glans, the genus was enriched in PCa subjects, while was more abundant in non-PCa subjects. In prostate, , , , and were the overrepresented genera in the PCa group, while , , sp., and were overrepresented in the non-PCa group. These findings provide a strong background for the development of potential biomarkers with clinical interest.
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关键词
glans penis,microbiota,prostate cancer,urinary tract,urine
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