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Dynamic Network-Guided CRISPRi Screen Identifies CTCF-loop-constrained Nonlinear Enhancer Gene Regulatory Activity During Cell State Transitions.

Renhe Luo,Jielin Yan,Jin Woo Oh,Wang Xi,Dustin Shigaki,Wilfred Wong,Hyein S. Cho,Dylan Murphy,Ronald Cutler,Bess P. Rosen,Julian Pulecio,Dapeng Yang,Rachel A. Glenn,Tingxu Chen,Qing V. Li,Thomas Vierbuchen,Simone Sidoli,Effie Apostolou,Danwei Huangfu,Michael A. Beer

Nature Genetics（2023）

Cited 17|Views54
Key words
Gene regulation,High-throughput screening,Mutagenesis,Stem cells,Systems analysis,Biomedicine,general,Human Genetics,Cancer Research,Agriculture,Gene Function,Animal Genetics and Genomics
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