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Defining Predictors of Weight Loss Response to Lorcaserin.

Aristea Sideri Gugger,Cara Dimino,Sunil K Panigrahi,Laurel Mayer,Richard M Smiley,Judith Korner,Sharon L Wardlaw

The Journal of clinical endocrinology and metabolism（2023）

Cited 0|Views19
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Abstract
Our results provide evidence that lorcaserin impacts the brain melanocortin system in humans and that effectiveness is increased in individuals with lower melanocortin activity. Furthermore, early changes in CSF POMC parallel WL-independent improvements in glycemic indexes. Thus, assessment of melanocortin activity could provide a way to personalize pharmacotherapy of obesity with 5HT2cR agonists.
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Key words
Cerebrospinal fluid,Insulin,Lorcaserin,Obesity,Proopiomelanocortin
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