Local anesthetic effects of lidocaine-loaded carboxymethyl chitosan cross-linked with sodium alginate hydrogels for drug delivery system, cell adhesion, and pain management
Journal of Drug Delivery Science and Technology(2023)
摘要
The development of hydrophilic carriers for drug encapsulation represents a current challenge. In this work lidocaine (LID) loaded with carboxymethyl chitosan (CCS) cross-linked with sodium alginate (SA) hydrogels were prepared to achieve the controlled release of LID drug. The mechanical characteristics of the CCS-SA hydrogels were examined via the swelling ratio, in vitro degradation, and rheological analysis. The as-prepared CCS-SA hydrogels were characterized by FTIR, XRD, and SEM analysis. The morphology of the CCS-SA hydrogels composites was confirmed porous structure. Satisfactory encapsulation and release characteristics were obtained for the LID-loaded CCS-SA hydrogels. Cytotoxicity assays test on Balb-c 3T3 cells confirmed that the LID-loaded CCS-SA hydrogels reduced its toxicity, relative to the free LID drug. The live/dead cell assay showed that the LID-loaded CCS-SA hydrogels using cell encapsulation study are nontoxic and cytocompatible toward Balb-c 3T3 cells. The anesthetic efficacy of LID-loaded CCS-SA hydrogels was evaluated using Balb/c mice. When administered in inflamed areas, LID-loaded CCS-SA hydrogels emerged as having stronger and longer analgesic effects. The measurement of CCS-SA hydrogels loaded with LID intravenously to tumor-bearing mice demonstrated active targeting in tumor tissues 24 h after injection. Based on these results, it appears that LID-loaded CCS-SA hydrogels have a local anesthetic effect that can effectively reduce injection times for postoperative pain management and limit the adverse effects of anti-inflammatory drugs.
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关键词
Hydrogels,Lidocaine,Balb-c 3T3 cells,In vivo toxicity,Anesthetics,Pain management
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