Improvement of antibacterial, anti-inflammatory, and osteogenic properties of OGP loaded Co-MOF coating on titanium implants for advanced osseointegration
Journal of Materials Science & Technology（2023）
Abstract
•A multifunctional and novel coating of TNT-ZO is successfully fabricated.•TNT-ZO substrates exhibit excellent antibacterial activity for MRSA elimination.•TNT-ZO substrates improve the crosstalk between RAW264.7 and MSCs via multiple paracrine signaling.•TNT-ZO substrates present the excellent osseointegration of peri‑implants in vivo.
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Key words
Titanium implants,Osteogenic growth peptide,Anti-inflammatory,Antibacterial activity,Osteoimmunomodulation
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