Dual functional cholinesterase and carbonic anhydrase inhibitors for the treatment of Alzheimer's disease: Design, synthesis, in vitro, and in silico evaluations of coumarin-dihydropyridine derivatives

•A new series of coumarin-dihydropyridines 6a-m has been synthesized as new inhibitors against ChEs and hCA isoforms i and II.•Some of the synthesized compounds were more potent than standard inhibitor tacrine against AChE.•Most of the synthesized compounds were more potent than standard drugs against BChE and hCA isoforms.•Compound 6f was the most active compound against AChE.•Compound 6i was the most active compound against BChE, hCA I, and II.•Docking study and in silico druglikeness/ADME/Toxicity prediction of the most potent compounds were also performed.