Microwave-assisted synthesis of 4,6-disubstituted isoindoline-1,3-diones by Diels-Alder reactions

•Chromones bearing an α,β-unsaturated carbonyl system enable the synthesis of highly functionalized 4,6-disubstituted isoindole-1,3-diones.•Microwave-assisted Diels-Alder reactions of 3-benzoylvinylchromones with readily available maleimides were performed.•The developed methodology occurs in one-pot, fair yields and affords biologically relevant scaffolds.