Gap junction is essential for the antidepressant effects of fluoxetine.

Cong-Yuan Xia,Ning-Ning Zhang,Hong Jiang,Yu-Xia Lou,Qian Ren,Xiao-Ling Zhang,Peng-Fei Yang,Qian-Hang Shao,Hao-Yu Zhu, Jiang-Fan Wan,Ya-Ni Zhang,Fang-Fang Li,Xu Yan,Shi-Feng Chu,Yi Zhang,Zhen-Zhen Wang,Nai-Hong Chen

The Journal of pharmacy and pharmacology（2023）

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摘要

Our study suggested that gap junction dysfunction blocks antidepressant effects of fluoxetine, contributing to understanding the mechanism underlying the time lag of fluoxetine.

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关键词

connexin,depression,fluoxetine,gap junction,time lag

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