Plerixafor and resatorvid inhibit hepatitis B virus in vitro by upregulating elongation factor Tu GTP-binding domain containing 2.

Frontiers in cellular and infection microbiology(2023)

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摘要
We established a convenient model for screening compounds that target EFTUD2 and further identified plerixafor and resatorvid as novel HBV inhibitors . Our findings provided information on the development of a new class of anti-HBV agents that act on host factors rather than viral enzymes.
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关键词
EFTUD2,hepatitis B virus,plerixafor,resatorvid,small-molecule agents
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