Vitamin A regulates tissue-specific organ remodeling in diet-induced obesity independent of mitochondrial function.

Ivanna Shymotiuk,Natali Froese,Christopher Werlein,Lea Naasner,Malgorzata Szaroszyk,Mark P Kühnel,Danny D Jonigk,William S Blaner,Adam R Wende,E Dale Abel,Johann Bauersachs,Christian Riehle

Frontiers in endocrinology（2023）

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摘要

The present study identifies an unexpected and tissue-specific role for VitA in DIO that regulates the pro-fibrotic transcriptional response and that results in organ damage independent of changes in mitochondrial energetics.

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关键词

diet-induced obesity,kidney,liver,mitochondria,skeletal muscle,type 2 diabetes,vitamin A

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