Soluble Urokinase Plasminogen Activator Receptor Contributes to ANCA-positive IgG-mediated Glomerular Endothelial Activation through TLR4 Pathway.
Current pharmaceutical design(2023)
摘要
uPAR protein can enhance the GEnC activation and injury induced by MPO-ANCA-positive IgG through the TLR4 pathway, indicating that suPAR may be involved in the pathogenesis of AAV and that su- PAR might be regarded as a potential therapeutic target.
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关键词
GEnC,TLR4,antineutrophil cytoplasmic antibody,bioinformatics analysis,uPAR,vasculitis
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