Soluble Urokinase Plasminogen Activator Receptor Contributes to ANCA-positive IgG-mediated Glomerular Endothelial Activation through TLR4 Pathway.

Fei Huang,Ranran Xu,Yiru Wang,Yongman Lv,Qingquan Liu

Current pharmaceutical design（2023）

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摘要

uPAR protein can enhance the GEnC activation and injury induced by MPO-ANCA-positive IgG through the TLR4 pathway, indicating that suPAR may be involved in the pathogenesis of AAV and that su- PAR might be regarded as a potential therapeutic target.

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关键词

GEnC,TLR4,antineutrophil cytoplasmic antibody,bioinformatics analysis,uPAR,vasculitis

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