Wei-Tong-Xin exerts anti-inflammatory effects through TLR4-mediated macrophages M1/M2 polarization and affects GLP-1 secretion.

Xiaoying Zhang,Xihan Yang,Shuanglin Zhang,Jinyu Wang,Mengshi Wang,Tiancheng Ma,Meiqi Wan,Xinyan Lv,Tingxu Yan,Ying Jia

The Journal of pharmacy and pharmacology（2023）

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摘要

Overall, WTX inhibited polarization of macrophages towards M1 phenotype but promoted the amounts of M2 phenotype, further the macrophages regulated by WTX alleviated GLP-1 content secreted by GLUTag cells. The aforementioned results were produced by WTX-mediated TLR4.

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关键词

GLP-1,M1/M2,TLR4,WTX,inflammation

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