A Functional Polymorphism in IL-1B Is Associated With Immune Reconstitution Inflammatory Syndrome of Chronic Disseminated Candidiasis.

Blandine Rammaert,Pierre-Yves Bochud,Anne-Sophie Brunel,Agnieszka Wojtowicz,Sophie Candon,Maria Pilar Gallego Hernanz,Olivier Lortholary

Open forum infectious diseases（2023）

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摘要

We investigated single nucleotide polymorphisms (SNPs) possibly involved in immune reconstitution inflammatory syndrome of chronic disseminated candidiasis (IRIS-CDC) through a candidate gene approach and a prospective matched-control study. We found that an SNP located in interleukin-1B at rs1143627 was significantly associated with the risk of developing IRIS-CDC.

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关键词

Candida spp,IL-1B,cytokines,genetic polymorphism,immune inflammatory reconstitution syndrome,invasive fungal diseases

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