Influence of Chronic Electroconvulsive Seizures on Plasticity-Associated Gene Expression and Perineuronal Nets Within the Hippocampi of Young Adult and Middle-Aged Sprague-Dawley Rats.

Minal Jaggar,Shreya Ghosh,Balaganesh Janakiraman,Ashmita Chatterjee,Megha Maheshwari, Vani Dewan,Brendan Hare,Sukrita Deb,Dwight Figueiredo,Ronald S Duman,Vidita A Vaidya

The international journal of neuropsychopharmacology（2023）

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摘要

Our findings indicate that age is a key variable in determining the nature of chronic ECS-evoked molecular and cellular changes in the hippocampus. This raises the intriguing possibility that chronic ECS may recruit distinct, as well as overlapping, mechanisms to drive antidepressant-like behavioral changes in an age-dependent manner.

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PNN,aging,antidepressant,hippocampal neurogenesis,hippocampus,parvalbumin,reelin

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