Breast Cancer With a HER2 FISH Group 2 Result: Should HER2 Tests be Repeated?

Minhua Wang,Qingqing Ding,Jun Gu,Steven M Sfamenos,Lei Huo,Zhenya Tang,Hongxia Sun,Melissa Robinson,Guilin Tang,Bora Lim, Yun Wu,Constance T Albarracin,Aysegul A Sahin,Hui Chen

Clinical breast cancer（2023）

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Abstract

Breast cancer with HER2 FISH group 2 result may represent heterogeneous populations of tumor cells being originated de novo or preferentially selected secondary to therapy. Repeat HER2 tests on alternative samples may be considered to guide anti-HER2 therapy.

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Key words

ASCO/CAP guidelines,FISH,HER2 amplification,Monosomy CEP17,heterogeneity

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