A new gentiopicroside derivative improves cognitive deficits of AD mice via activation of Wnt signaling pathway and regulation of gut microbiota homeostasis.
Phytomedicine : international journal of phytotherapy and phytopharmacology（2023）
Abstract
2H-GPS improves the symptoms of AD mice through combination of the regulation of Wnt signaling pathway and the microbiota-gut-brain axis, and the mechanism of action of 2H-GPS is distinct from that of Done.
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Key words
AD mice,Gut microbiota,Memory,Microglia,Tau protein,Wnt signaling pathway
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