HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury

Ling Chen,Mingli Mao,Dandan Liu,Wenjia Liu,Yajuan Wang,Lihua Xie,Yingcheng Deng,Yi Lin,Yang Xu,Xiaolin Zhong,Wenyu Cao

International Immunopharmacology（2023）

Cited 0|Views23

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Abstract

•HC067047 blocked excess oxidative stress in endotoxemia colons.•TRPV4 inhibition maintained mitochondrial biological function and prevented mitophagy.•Inflammatory pyroptosis in endotoxemia colons were attenuated by HC067047 treatment.•HC067047 rescued colonic barrier dysfunction in endotoxemia mice.

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Key words

TRPV4,HC067047,Oxidative stress,Mitophagy,Inflammatory pyroptosis

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