Biosynthesis of Tetronates by a Nonribosomal Peptide Synthetase-Polyketide Synthase System
Organic letters(2023)
摘要
A cryptic tetronate biosynthetic pathway was identified in Kitasatospora niigatensis DSM 44781 via heterologous expression. Distinct from the currently known biosynthetic pathways, this system utilizes a partially functional nonribosomal peptide synthetase and a broadly selective polyketide synthase to direct the assembly and lactonization of the tetronate scaffold. By employing a permissive crotonyl-CoA reductase/carboxylase to provide different extender units, seven new tetronates (kitaniite-tronins A-G) were obtained via precursor-directed biosynthesis.
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关键词
nonribosomal peptide synthetase–polyketide,biosynthesis,tetronates
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