Indirect bilirubin impairs invasion of osteosarcoma cells via inhibiting the PI3K/AKT/MMP-2 signaling pathway by suppressing intracellular ROS.

Xuhui Yuan,Cong Ma,Jiayu Li,Junhong Li,Ronghui Yu,Feng Cai,Gaoyang Qu,Bo Yu,Lang Liu,Duo Zeng,QuanHui Jiao,Qi Liao,Xiaobin Lv

Journal of bone oncology（2023）

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摘要

IBIL may serve as an independent prognostic predictor for osteosarcoma patients. IBIL impairs invasion of osteosarcoma cells through repressing the PI3K/AKT/MMP-2 pathway by suppressing intracellular ROS, thus inhibiting its metastatic potential.

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关键词

AUC, area under curve,BRNP, PEGylated bilirubin nanoparticles,CCK-8, cell counting kit-8,CI, confidence interval,DBIL, direct bilirubin,DMSO, dimethyl sulfoxide,ECM, extracellular matrix,H2O2, hydrogen peroxide,HIF-1α, hypoxia inducible factor-1α,HR, hazard ratio,IBIL,IBIL, indirect bilirubin,Invasion,MDA, malondialdehyde,MMP, matrix metalloproteinase,OS, overall survival,Osteosarcoma,PFS, progression-free survival,PI3K/AKT/MMP-2,PVDF, polyvinylidene fluoride,Prognosis,ROC, receiver operative characteristic,ROS, reactive oxygen species,SD, standard deviation,SOD, superoxide dismutase,TBIL, total bilirubin,TIMP, tissue inhibitor of matrix metalloproteinase,VEGF, vascular endothelial growth factor,qRT-PCR, real-time quantitative PCR

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