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Cardiac Toxicity of Alectinib in Patients With ALK+ Lung Cancer: Outcomes of Cardio-Oncology Follow-Up

Melinda A Pruis,G D Marijn Veerman,H Carlijne Hassing,Daan A C Lanser,Marthe S Paats,Ron H N van Schaik,Ron H J Mathijssen,Olivier Manintveld,Anne-Marie C Dingemans

JACC: CardioOncology（2023）

Cited 3|Views16
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Abstract
No patients showed signs of a diminished left ventricular ejection fraction. Alectinib caused more bradycardia than previously reported (42%) with some instances of severe symptomatic bradycardia. Patients with severe toxicity generally had an elevated exposure above the therapeutic threshold.
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alectinib,anaplastic lymphoma kinase,bradycardia,cardio-oncology,non-small cell lung cancer
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