Redirecting T-cell Activity with Anti-BCMA/Anti-CD3 Bispecific Antibodies in Chronic Lymphocytic Leukemia and Other B-cell Lymphomas.

Anne W J Martens,Joanne M Rietveld,Renate de Boer,Fleur S Peters, An Ngo,Lotte W H G van Mil,Koen de Heer,Marcel Spaargaren,Christie P M Verkleij,Niels W C J van de Donk,Homer C Adams,Eric Eldering,Carel J M van Noesel,Raluca Verona,Arnon P Kater

Cancer research communications（2022）

Cited 3|Views7

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Abstract

Besides reported BCMA expression on multiple myeloma, we demonstrate BCMA can be detected and enhanced using γ-secretase inhibition on cell lines and primary material of various B-cell malignancies. Furthermore, using CLL we demonstrate that low BCMA-expressing tumors can be targeted efficiently using the BCMAxCD3 DuoBody teclistamab.

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Key words

chronic lymphocytic leukemia,lymphomas,antibodies,t-cell,anti-bcma,b-cell

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