Therapeutic effect of human ApoA-I-Milano variant in aged transgenic mouse model of Alzheimer's disease.

Montse Solé,Paula Marazuela,Laura Castellote,Anna Bonaterra-Pastra,Lydia Giménez-Llort,Mar Hernández-Guillamon

British journal of pharmacology（2023）

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摘要

Peripheral hrApoA-I-M treatment shows a beneficial impact on working memory, involving mechanisms related with brain Aβ mobilization and modulation of the levels of cerebrovascular markers. Our study shows the potential therapeutic applicability of a safe and non-invasive treatment based on peripheral administration of hrApoA-I-M in AD.

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Alzheimer's disease,ApoA-I-Milano,Apolipoprotein A-I,beta-amyloid,cerebrovasculature,drug reprofiling,receptor for advanced glycation end products

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