Real-time analysis of dynamic compartmentalized GSH redox shifts and H2O2 availability in undifferentiated and differentiated cells

Brandon M. Davies,Jenna K. Katayama,Joshua E. Monsivais,James R. Adams,Miriam E. Dilts,Arielle L. Eberting,Jason M. Hansen

Biochimica et biophysica acta. General subjects（2023）

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摘要

•Undifferentiated cells are more prone to redox shifts than differentiated cells.•Differentiated cells have higher glutathione and antioxidant gene expression.•A chemical inducer of Nrf2 prevents oxidizing shifts in undifferentiated cells.•roGFP provides real-time, compartmentalized measurements of redox shifts in neurons.

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关键词

Glutathione,Hydrogen peroxide,Neurogenesis,Nuclear factor erythroid-2-related factor 2,Redox state,Redox-sensitive green fluorescent protein

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