Preparation of [ 68 Ga]Ga-Chloride from 68 Zn solid target for the synthesis of pharmaceutical grade [ 68 Ga]Ga-PSMA-11 and [ 68 Ga]Ga-DOTA-TATE.

Sankha Chattopadhyay,Shayantani Ash, D G Mahesh,Luna Barua,Arpit Mitra,Sujata Saha Das, Samarjit Singha, Md Alam Nayer, Madhusmita,Umesh Kumar,Samarendu Sinha

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine（2023）

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摘要

Ga is produced from enriched zinc-68 target electrodeposited on copper base material which was irradiated with 15 MeV proton energy in 30 MeV cyclotron. A modified semi-automated separation and purification module was used to obtain pharmaceutical grade [Ga]GaCl in 35 ± 5 min. The quality of [Ga]GaCl produced was in accordance with Pharmeuropa 30.4. The [Ga]GaCl was utilized for the formulation of multiple doses of [Ga]Ga-PSMA-11 and [Ga]Ga-DOTATATE. The quality of [Ga]Ga-PSMA-11 and [Ga]Ga-DOTATATE were also in accordance with Pharmacopeia.

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关键词

Pharmacopeia,Radiochemical,[(68)Ga]Ga-PSMA-11 and [(68)Ga]Ga-DOTATATE,[(68)Ga]GaCl(3)

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