An in vitro study of the effects of Phellodendron bark extract and berberine chloride on periodontal pathogenic bacteria in the oral microbiome.

Takuma Okuda,Ryutaro Jo,Kota Tsutsumi,Daisuke Watai,Chikako Ishihara,Kazuma Yama,Yuto Aita,Takuya Inokuchi,Mitsuo Kimura,Takashi Chikazawa,Eiji Nishinaga, Koji Yamamoto

Journal of oral biosciences（2023）

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摘要

Our findings suggest that PBE and BC reduce the relative abundance of periodontal pathogenic bacteria in the oral microbiome. Thus, PBE and BC can aid in preventing periodontal disease, given their ability to regulate the oral microbiome composition and their anti-inflammatory effects.

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关键词

16S rRNA gene sequencing,Berberine chloride,Oral microbiome,Periodontal disease,Phellodendron bark extract

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