First-in-class Microbial Ecosystem Therapeutic 4 (MET4) in combination with immune checkpoint inhibitors in patients with advanced solid tumors (MET4-IO trial).

A Spreafico,A A Heirali,D V Araujo,T J Tan,M Oliva,P H H Schneeberger,B Chen, M K Wong, L-A Stayner, A R Hansen, S D Saibil, B X Wang, K Cochrane, K Sherriff,E Allen-Vercoe, W Xu,L L Siu,B Coburn

Annals of oncology : official journal of the European Society for Medical Oncology（2023）

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摘要

This trial is the first report of the use of a microbial consortium as an alternative to FMT in advanced cancer patients receiving ICI and the results justify the further development of microbial consortia as a therapeutic co-intervention for ICI treatment in cancer.

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advanced solid tumors,first in class microbial ecosystem therapeutic 4,immune checkpoint inhibitors,intestinal microbiome

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