MicroRNA-146a-5p alleviates the pathogenesis of osteoarthritis by inhibiting SDF-1/CXCR4-induced chondrocyte autophagy

Tengyun Yang,Canzhang Li,Yanlin Li,Guofeng Cai,Guoliang Wang,Lu He, Chuan He

International Immunopharmacology（2023）

引用 2|浏览14

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摘要

•SDF-1/CXCR4 promotes OA development by enhancing chondrocyte autophagy.•MicroRNA-146a-5p suppress CXCR4 mRNA expression and SDF-1/CXCR4-induced autophagy.•Administration of miR-146a-5p significantly alleviated OA.

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关键词

Osteoarthritis,MicroRNA,Stromal Cell-Derived Factor 1,C-X-C Chemokine Receptor Type 4,Autophagy

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