Healthy Vaccinee Bias and MenB-FHbp Vaccine Effectiveness Against Gonorrhea.

Winston E Abara,Kyle T Bernstein,Felicia M T Lewis,Preeti Pathela,Aras Islam,Michael Eberhart,Iris Cheng,Alexandra Ternier,Jennifer Sanderson Slutsker,Robbie Madera,Robert Kirkcaldy

Sexually transmitted diseases（2023）

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Abstract

ABSTRACT:Observational studies demonstrated 30% to 40% effectiveness of outer-membrane vesicle (OMV) meningococcal serogroup B vaccines against gonorrhea. To explore whether healthy vaccinee bias influenced such findings, we examined the effectiveness of MenB-FHbp, a non-OMV vaccine that is not protective against gonorrhea. MenB-FHbp was ineffective against gonorrhea. Healthy vaccinee bias likely did not confound earlier studies of OMV vaccines.

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